Activities

oUR Research

Diverse range of our multidisciplinary projects focus on characterising molecular mechanisms which regulate endothelial cell properties and function in health and chronic diseases and development of fully humanised, and thus clinically relevant, in vitro models using these cells and enabling to mimic complex human systems. 

TIMELINE

Projects

This project aims to uncover mechanisms of resistance in kidney cancer. The project utilises state of the art co-culture models to deconvolute resistance mechanisms aiming to develop new treatments for this chronic disease. 

This project aims to uncover mechanisms of resistance in melanoma. The project utilises state of the art co-culture models to deconvolute resistance mechanisms aiming to develop new treatments for this chronic disease. 


This project aims to uncover the role of endothelial cells in chronic lung disease. The project develops a humanised model focused on accurately representing endothelial heterogeneity and characterising alterations to this heterogeneity in chronic lung disease. This work aims to develop new avenues for therapeutic management for chronic lung diseases. 

This project aims to provide novel biological insights in pharmacological properties of human endothelial cells. This project utilises a mass spectrometry-based label-free quantitative proteomics pipeline in conjunction with High Performance Computer VIPER. 

This project aims to isolate high-purity genomic DNA from pancreatic cyst fluid samples and perform whole genome sequencing analysis of pancreatic cancer samples in comparison to the reference genome to identify disease-related variants.


This project aims to analyze pancreatic cystic fluid samples using next generation genomic sequencing and proteomic analyses to discover new regulatory molecules to determine the potential of these molecules to serve as markers to detect early changes towards pancreatic cancer.


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publications AND PRE-PRINTS

Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells (Conference Abstract)

Matthew A. Morfitt, John Greenman, Anthony Maraveyas, Adrian L. Harris, Leonid L. Nikitenko


Calcitonin receptor-like receptor agonists induce p44/42 MAPK phosphorylation in VEGF-A-stimulated human blood endothelial cells after bevacizumab treatment (Conference Abstract)

Matthew A. Morfitt, John Greenman, Anthony Maraveyas, Leonid L. Nikitenko


Establishing de novo platform for whole genome sequencing of pancreatic cyst fluid for early detection and diagnosis of pancreatic cancer (Conference Abstract)

Adenike Adekeye, Farzana Haque, Camille Ettelaie, Leonid Nikitenko, Anthony Maraveyas


Novel protein Interaction Network of Human Calcitonin Receptor-like Receptor Revealed by Label-Free Quantitative Proteomics (Pre-Print)

Dimitrios Manolis, Shirin Hasan, Camille Ettelaie, Anthony Maraveyas, Darragh P. O’Brien,  Benedikt M. Kessler, Holger Kramer, Leonid L. Nikitenko


Altered Heterogeneity of Ageing Lung Endothelium is a Hallmark of Idiopathic Pulmonary Fibrosis (Pre-Print)

Eamon C. Faulkner, Adam A. Moverley,  Simon P. Hart, Leonid L. Nikitenko


MYPT1 is a non-canonical AKAP that tethers PKA to the MLCP signaling node (Pre-Print)

Jawad S Khalil, Paulo A. Saldanha, Connor M Blair, Jiayue Ling, Wei Ji, George S. Baillie, Khalid M Naseem, Leonid L Nikitenko, Francisco Rivero


Complex transcriptional profiles of the PPP1R12A gene in cells of the circulatory system as revealed by in silico analysis and reverse transcription PCR

Paulo A. Saldanha, Olapeju I. Bolan, Timothy M. Palmer, Leonid L. Nikitenko, Francisco Rivero

A Patients Guide to Pulmonary Fibrosis (2nd edition)

Karolina  Jagielka, Eamon C. Faulkner, Simon P. Hart, Leonid L. Nikitenko

Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms 

Sophie Featherby, Yu Pei Xiao, Camille Ettelaie,  Leonid L. Nikitenko, John Greenman, Anthony Maraveyas


Conference Attendance 


the LONDON PANCREAS WORKSHOP 2023

1-5 October 2022
ICLAF 2022 Logo
28-29 June 2022
Modernising Medical Research Logo

Outreach activities

Other Activities

Endothelial Cell Biology Health *GDP PhD Cluster

Multi disciplinary group of which includes eight fundamental science and clinical academics supporting three PhD students at the University of Hull. The cluster focuses on Human endothelial cells in health and chronic disease through translational research and computational analysis pipelines.

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Endothelial Cell Journal Club

The journal club is a student run bi-weekly meeting where we discuss and present relevant papers to keep us up to date on developments in the field and develop our presentation and peer reviewing skills. 

ECRF

The endothelial cell research fund (ECRF) is to support undergraduate and postgraduate students conducting research projects in the field of endothelial cell biology (travel, reagents etc.) and also including invitation of the external speakers for giving talks on endothelial cell research at the Endothelial Cell Journal Club Meetings and the University of Hull Biomed/CAM Seminars.

The account is now open and ready to receive donations. If you wish to support the ECR fund, please find enclosed the links to the online pages for either single gifts or direct debits:

https://alumni.hull.ac.uk/DARODonationForm

In the Designation section the donor would need to choose "ECR Fund".

For Previous publications, access our ARCHIVE